Formulation and Characteristics of Hydrogel Patch Containing Pineapple Peel (Ananas comosus L.) Ethanol Extract
Abstract
Abstract
Pineapple peel (Ananas comosus L.) contains bioactive compounds such as flavonoids and the enzyme bromelain, which possess antioxidant, anti-inflammatory, antibacterial, and anticancer properties, and the ability to accelerate wound healing. Hydrogel patches, as a formulation for transdermal delivery, are effective in wound healing due to their hydrophilic properties that maintain moisture and prevent bacterial infection in open wounds. This study aims to develop and test the characteristics of hydrogel patch formulations containing ethanol extracts of pineapple peel with varying concentrations of 10%, 20%, and 30%, compared to a control (hydrogel patch without pineapple peel extract). A series of evaluation tests were conducted to assess the patch characteristics, including organoleptic tests, pH, absorbency, weight uniformity, swelling ratio, patch thickness, and folding endurance. The results showed that the concentration of pineapple peel extract affects the hydrogel patch characteristics. The higher the extract concentration, the darker the patch color, but the pH, absorbency, and swelling ratio decrease. Patches with higher extract concentrations also showed an increase in weight. Absorbency tests indicated that none of the formulas met the acceptance criteria (<10%), with absorbency results of 22.97%, 11.60%, and 21.95% for 10%, 20%, and 30% extract concentrations, respectively, and 23.43% for the control. Swelling ratio and thickness tests showed the best results for the control, followed by the 10%, 20%, and 30% extract concentrations. The folding endurance test showed that the control and 10% extract formula had good results (>300 folds), while higher extract concentrations reduced the folding endurance of the hydrogel patch
.Keywords: extract, pineapple peel, hydrogel patch, formulation, patch characteristics
References
'1. Badan Pusat Statistik Indonesia. 2023. Produksi Tanaman Buah-buahan, 2021-2022. URL: https://www.bps.go.id/id/statistics-table/2/NjIjMg%3D%3D/produksi-tanaman-buah-buahan.html. Diakses pada 14 Februari 2024
'2. Baharudin, A., & Maesaroh, I. (2020). Formulasi Sediaan Patch Transdermal Dari Ekstrak Bonggol Pohon Pisang Ambon (Musa paradisiaca var. sapientum) Untuk Penyembuhan Luka Sayat. Journal Of Herbs and Farmakological, 2(2), 55–62.
'3. Fuziyanti, N., Najihudin, A., & Hindun, S. (2022). Pengaruh Kombinasi Polimer PVP:EC dan HPMC:EC Terhadap Sediaan Transdermal Pada Karakteristik Patch yang Baik : Review. Pharmaceutical Journal of Indonesia, 7(2), 147–152. https://doi.org/10.21776/ub.pji.2022.007.02.10
'4. Galaktomanan, P., Rahayuningdyah, D. W., Lyrawati, D., Widodo, F., Puspita, O. E., & Polymers, P. V. P. (2020). Pengembangan Formula Hidrogel Balutan Luka Menggunakan Kombinasi Development of Wound Hydrogel Dressing Formula Using a Combination of. 5(2), 117–122.
'5. Harliantika, Y., & Noval, N. (2021). Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M (Formulation and Evaluation Hydrogel of Agarwood Leaf (Aquilaria malacensis Lamk.) Extract Ethanol with Combination Ca. Journal of Pharmaceutical Care Anwar Medika, 3(2), 55–70.
'6. Hermanto, F. J., & Nurviana, V. (2019). Evaluasi Sediaan Patch Daun Handeuleum (Graptophyllum Griff L) Sebagai Penurun Panas. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan Dan Farmasi, 19(2), 209. Https://Doi.Org/10.36465/Jkbth.V19i2.499
'7. Ilkhawati, S. A., Ikasari, E. D., & Indriyanti, E. (2023). Formulasi Dan Optimasi Kadar Hydroxypropyl Methylcellulose K100m Dan Polyvinyl Acetate Dalam Sediaan Patch Transdermal Propranolol Hcl. Medical Sains : Jurnal Ilmiah Kefarmasian, 8(2), 405–414. Https://Doi.Org/10.37874/Ms.V8i2.671
'8. Omorotionmwan, F. O.-O., Ogwu, H. I., & Ogwu, M. C. (2019). Antibacterial Characteristics And Bacteria Composition Of Pineapple (Ananas Comosus [Linn.] Merr.) Peel And Pulp. Food And Health, July, 1–11. Https://Doi.Org/10.3153/Fh19001
'9. Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An Overview. Journal Of Nutritional Science, 5. Https://Doi.Org/10.1017/Jns.2016.41
'10. Patel, J. K., & Jani, R. K. (2016). Enhancing Effect Of Natural Oils As Permeation Enhancer For Transdermal Delivery Of Diltiazem Hydrochloride Through Wistar Rat Skin. International Journal Of Pharmaceutical Sciences Review And Research, 36(1), 9–16.
'11. Ramadhan, W., Islami,D., & Iballa, D.B.M. (2024). Uji Aktivitas Antibakteri Nanoemulsi Ekstrak Kulit Nanas (Ananas Comosus L. Merr). Jurnal JFARM, 2(1), 20 – 27.
'12. Reiza, I. A., Rijai, L., & Mahmudah, F. (2019). Skrining Fitokimia Ekstrak Etanol Kulit Nanas (Ananas Comosus (L.) Merr). Proceeding Of Mulawarman Pharmaceuticals Conferences, 10, 104–108.Https://Doi.Org/10.25026/Mpc.V10i1.371
'13. Varilla, C., Marcone, M., Paiva, L., & Baptista, J. (2021). Bromelain, A Group Of Pineapple Proteolytic Complex Enzymes (Ananas Comosus) And Their Possible Therapeutic And Clinical Effects. A Summary. Foods, 10(10). Https://Doi.Org/10.3390/Foods10102249
'14. Wardani, V. K., & Saryanti, D. (2021). Formulasi Transdermal Patch Ekstrak Etanol Biji Pepaya (Carica Papaya L.) Dengan Basis Hydroxypropil Metilcellulose (Hpmc). Smart Medical Journal, 4(1), 38. Https://Doi.Org/10.13057/Smj.V4i1.43613