PERBEDAAN ZONA HAMBAT CIPROFLOKSASIN DENGAN EKSTRAK KURMA (Phoenix dactylifera) TERHADAP BAKTERI GRAM NEGATIF SECARA IN VITRO
Abstract
Date palm fruit (Phoenix dactylifera) is a fruit that has many benefits such as antioxidant,
anti-bacterial, and anti-cancer effects. Dates also contain phytochemicals such as
polyphenols (flavonoids, isoflavones, lignin and phenolic acids), tannins, carotenoids, and
sterols. This study aims to determine the activity of ciprofloxacin and dates (Phoenix
dactylifera) against gram negative bacteria.
This is an experimental laboratory research with a post-test only control group
design. Bacterial activity was assessed based on the diameter of the inhibition zone in Muller
Hinton agar with Kirby Bauer method. The gram-negative bacteria tested were Escherichia
coli and Klebsiella pneumoniae from clinical isolates that had been identified using VITEK®
2. The concentration of the test bacteria was 0.5 Mac Farlan. The dates extract used was
Ajwa dates extract ripe at 100% concentration using the socletation method with methanol
solvent. The test group was divided into 3 groups, namely the ciprofloxacin group only, the
ciprofloxacin group and the date palm extract, the date palm extract group only.
There is no significant difference (P > 0.05) in the activity of ciprofloxacin and
ciprofloxacin with date palm extract against E. coli and Klebsiella pneumonia bacteria.
There was no difference in the activity of ciprofloxacin or ciprofloxacin with the
addition of Ajwa date extract.
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