Optimasi Formula Krim Ekstrak Etanol Daun Kelor (Moringa oleifera Lamk) Dengan Emulgator Span 80 Dan Tween 80
Abstract
Moringa plant (Moringa Oleifera Lamk) contains various free radical inhibitory molecules, such as phenolic compounds (phenolic acids, flavonoids, quinones, coumarins, lignans, stilbenes, tannins), nitrogen compounds (alkaloids, amines, betalains), vitamins, terpenoids (including carotenoids). ), and several other endogenous metabolites rich in antioxidant activity. When span 80 and tween 80 are mixed in a suitable composition and in their manufacture the aqueous phase is dispersed into the oil, span 80 and tween 80 will be arranged alternately at the interface of the oil phase and water phase forming a monolayer that surrounds the droplets so as to produce good emulsifying properties. and form a stable O/A type emulsion. In this study, concentration variations were carried out to see the optimum formula for the ethanol extract of Moringa leaf cream with a mixture of span 80 and tween 80 to see the best physical properties. The cream was made in 5 formulas with variations of span 80 and tween 80 using the Simplex Lattice Design method with the parameters of adhesion, dispersion, pH, viscosity, and protective power. Data that were normally distributed were followed by One Sample T-test, one sample with 95% confidence level. The optimum formula is found in a concentration ratio of span 80: tween 80 (0:1) with a desirability value obtained that is 0.986.
References
Allen, L. V., 2002, The Art Science, and Technology of Pharmaceutical Compounding, Edisi 2, American Pharmaceutical Association, Washington.
Anief, M. 1997. Formulasi Obat Topikal dan Dasar Penyakit Kulit. Gadjah Mada Universty Press. Yogyakarta. Hlm 30-39
Anief, M., 2005, Manajemen Farmasi.Yogyakarta:Gadjah Mada University Press.
Andersen, M., Markham, K.R. 2006. Flavonoids. Taylor & Francis Group. New York Anonim. 1979. Farmakope Indonesia. Edisi III. Hal 6-9. Departemen Kesehatan Republik Indonesia: Jakarta
Anonim. 1986. Sediaan Galenik. Jakarta: Departemen Kesehatan Republik Indonesia
Depkes RI, 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Direktorat Jendral Pengawasan Obat dan Makanan, Jakarta.
Derjen POM, 1987. Analisis Obat Tradisional. Direktorat Jendral Pengawasan Obat dan Makanan R. I., Jakarta.
Harbone, J.B., 1987. Metode Fitokimia : Penuntun Cara Modern Menganalisis Tumbuhan. Institut Teknologi Bandung, Bandung.
Hardiyanthi, F., 2015. Pemanfaatan Aktivitas Antioksidan Daun Kelor (Moringa oleifera L.) Dalam Sediaan Hand and Body Cream, Universitas Islam Negeri Syarif Hidayatullah, Jakarta.
Luthfiyah Fifi. 2012. Potensi Gizi Daun Kelor (Moringa oleifera) Nusa Tenggara Barat. Media Bina Ilmiah, ISSN No. 1978-3787. Volume 6, N0. 2, Maret 2012.
Mardiana, Lina. 2013. Daun Ajaib Tumpas Penyakit. Jakarta : Penebar Swadaya. Rajanandh MG, Satishkumar MN, Elango
K, Suresh B, 2012, Moringa oleifera Lam. A Herbal Medicine for Hyperlipidemia: A Pre-clinical Report, Department of Pharmacology, J.S.S University, India
Rathi BS, Bodhankar SL, dan Baheti AM., 2006. Evaluation of Aqueous Leaves Extract of Moringa oleifera Linn for Wound Healing In Albino Rats. Indian Journal of Experimental Biology. 4:898-901.
Robinson, Trevor. 1995. Kandungan Organik Tumbuhan Tinggi. Bandung: Institut Teknologi Bandung
Rollof, M.M., Weisgerber, U., Lang, B., dan Stimm, 2009. Moringa Oleifera LAM. WILLEY-VCH Verlag GmbH & Co. KgaA, Weinheim.
Sirait, M. 2007. Penuntun Fitokimia Dalam Farmasi. ITB. Bandung.
Syaifullah, T. N. dan Kuswahyuning, R. 2008. Teknologi dan Formulasi Sediaan Semipadat. Yogyakarta : Pustaka Laboratorium Teknologi Farmasi fakultas Farmasi Universitas Gadjah Mada. Hal 73-109
Syamsuni, 2006. Farmasetika Dasar Dan Hitungan Farmasi. Penerbit Buku Kedokteran EGC, Jakarta.
Umarudin., R. Susanti., dan A. Yuniastuti. (2012). Efektivitas Ekstrak Tanin Seledri terhadap Profil Lipid Tikus Putih Hiperkolesterolemi. Unnes Journal of Life Science. 1(2): 78-85.