Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method

Keywords: direct compression, fast disintegrating tablet, red ginger

Abstract

Red ginger (Zingiber officinale Roxb) is one of the medicinal plants that is effective as a medicine for nausea and vomiting. One of the techniques for developing traditional medicinal products is to make fast disintegrating tablets (FDT). This research aims to compare the effect of these various disintegrating materials on the physical properties of FDT. FDT red ginger extract is made using the direct compression method. The tablets obtained were physically evaluated including weight uniformity, hardness, friability, and disintegration time. The statistical results using the one-way ANOVA test show that between tablet formulas there are significant differences in tablet disintegration time with differences in the type of disintegrating agent. The data obtained shows that all formulas meet the physical properties test requirements for tablets. The tablet formula using crospovidone produces tablets with high hardness, low friability, and fast disintegration time

References

'1. Akdag, Y., Gulsun, T., Izat, N., Cetin, M., Oner, L., & Sahin, S. (2020). Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct compression and lyophilization methods. Journal of Drug Delivery Science and Technology, 57, 101760.

'2. Anil, P. A., Solanki, K. P., Pandya, V., & Dholakia, S. (n.d.). Fast Dissolving Tablets : As a Preferred Alternative to conventional tablets. 8(3), 171–186.

'3. Balasubramaniam, J., Bindu, K., Rao, V. U., Ray, D., Haldar, R., & Brzeczko, A. W. (2008). Effect of superdisintegrants on dissolution of cationic drugs. Dissolution Technologies, 15(2), 18–25. https://doi.org/10.14227/DT150208P18

'4. Berardi, A., Bisharat, L., Quodbach, J., Rahim, S. A., Perinelli, D. R., & Cespi, M. (2021). Advancing the understanding of the tablet disintegration phenomenon–an update on recent studies. International Journal of Pharmaceutics, 598, 120390.

'5. Chauhan, K., Solanki, R., & Sharma, S. (2018). A review on fast dissolving tablet. International Journal of Applied Pharmaceutics, 10(6), 1–7. https://doi.org/10.22159/ijap.2018v10i6.28134

'6. Depkes RI. (2020). Farmakope Indonesia edisi VI. In Departemen Kesehatan Republik Indonesia.

'7. Desai, P. M., Liew, C. V., Wan, P., & Heng, S. (2016). Review of Disintegrants and the Disintegration Phenomena. Journal of Pharmaceutical Sciences, 1–11. https://doi.org/10.1016/j.xphs.2015.12.019

'8. Dhakal, B., Thakur, J. K., Mahato, R. K., Rawat, I., Rabin, D. C., Chhetri, R. R., Shah, K. P., Adhikari, A., & Pandey, J. (2022). Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters. 2022.

'9. Gautam, D., & Talwan, P. (2023). Formulation Aspects and Manufacturing Technology – A Review on Fast Disintegrating Tablets. January. https://doi.org/10.37896/YMER22.01/93

'10. Ginger, R., & Pichika, M. R. (2022). Zingiber officinale var. rubrum : Red Ginger’s Medicinal Uses.

'11. Haruna, F., Apeji, Y. E., Oparaeche, C., Oyi, A. R., & Gamlen, M. (2020). Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression. Future Journal of Pharmaceutical Sciences, 6, 1–9.

'12. Joshi, R., Garud, N., & Akram, W. (2020). Fast Dissolving Tablets : A Review. 11(October 2021). https://doi.org/10.13040/IJPSR.0975-8232.11(4).1562-70

'13. Juan, C., Gallo, L., & Gonzalez Vidal, N. (2024). Development of Losartan Orally Disintegrating Tablets by Direct Compression: a Cost-Effective Approach to Improve Paediatric Patient’s Compliance. AAPS PharmSciTech, 25(4), 79.

'14. Mahran, M., Helmy, O., Hussein, A., Ahmed, A. F., & Sharawe, M. A. (2020). Fast disintegrating tablets of spray dried poly-herbal extract : a promising hypoglycemic and diabetic wound healing activity. 3, 23–30.

'15. Mohamed, M. B., Talari, M. K., Tripathy, M., & Majeed, A. B. A. (2012). Pharmaceutical applications of crospovidone: a review. International journal of drug formulation and research, 3(1), 19.

'16. Nagaveni, P., Sreevalli, A., & Sundar, G. S. (2023). Fast Dissolving Tablets: An Overview. International Journal of Pharmaceutical Sciences, 1(07), 1.

'17. Nugraheni, R. W., Putra, G. A., & Ermawati, D. (2023). Optimization of Tablet Formulations Containing Green Robusta Coffee Beans (Coffea canephora) Extract with Various Concentrations of Sodium Starch Glycolate As a Disintegrant. KnE Medicine, 284–289.

'18. Rahmawati, T. E., & Nursoleha, E. (2022). Formulasi Fast Disintegrating Tablets Difenhidramin HCl Menggunakan Kombinasi SSG Dan Crospovidone Sebagai Disintegrant. Journal Pharmacy Aisyah, 1(1), 1–5.

'19. Rahmawati, T. E., Siswanto, A., & Djalil, A. D. (2023). Optimization of Fast Disintegrating Tablets Diphenhydramine HCl using Co-process of Cross-link Yellow Kepok Banana Starch, Crospovidone, and Microcrystalline Cellulose. Jurnal Ilmu Kefarmasian Indonesia, 21(2), 231. https://doi.org/10.35814/jifi.v21i2.1406

'20. Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009). et al.(2006). Handbook Of Pharmaceutical Excipients. The Pharmaceutical Press, London.

'21. Rustiani, E., & Andini, S. (2019). Formulasi Fast Desintegrating Tablet ( FDT ) Sari Buah Jambu Biji Merah dengan Perbedaan Konsentrasi Ac-Disol. Pharmaceutical and Biomedical Sciences Journal, 1(1), 13–20.

'22. Sabirin, S., Darussalam, A., Kusarpoko, B., Safrudin, A., Mawarni, G. K., Suparman, S., & Musa, M. (2024). The use of partially pregelatinized starch from cassava as disintegrant. AIP Conference Proceedings, 2957(1).

'23. Sheth, B. B., Bandelin, F. J., & Shangraw, R. F. (1980). Compressed tablets. Pharmaceutical dosage forms: Tablets, 1, 109–185.

'24. Sigit Pratama, A. F. (2022). Formulasi Dan Evaluasi Kitosan Sebagai Disintegrant Pada Fast Disintegrating Tablet Ekstrak Biji Adas (Foeniculum vulgare). Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK), 20(1), 28–36.

'25. Trisopon, K., & Kittipongpatana, O. S. (2019). Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique. Starch/Staerke, 71(5–6), 1–8. https://doi.org/10.1002/star.201800220

Published
2024-10-28
How to Cite
RAHMAWATI, T. E. (2024). Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method . Media Farmasi Indonesia, 19(2), 130-136. https://doi.org/10.53359/mfi.v19i2.278