Determination Of Dissolution Profile Sprinkle Formulation From Noni Fruit Extract (Morinda Citrifolia L.)
Abstract
Background: Noni fruit (Morinda citrifolia L.) has immunomodulatory properties due to the presence of scopolamine and quercetin compounds. This immunomodulator activity will be utilized in pharmaceutical products formulated into fine granules (sprinkle formulation). Objective: In this study, dissolution testing of the formulation will be conducted using a type 2 (paddle) apparatus and a medium with a pH value of 1.2 and 4.5. Method: The sprinkle formulation was prepared with the following composition: 16.67% extract, 2.70% Povidone, 2.29% SSG, 20% Mannitol, 3% Aspartame, 0.5% Mg.Stearate, and 54.84% Lactose. The formulation was then subjected to physical granule quality testing and dissolution testing. In the dissolution test, the levels of samples taken during the dissolution test were determined using UV-Vis spectrophotometry. Results: The results obtained were the dissolution profile of quercetin compounds in the sprinkle formulation of noni fruit extract (Morinda citrifolia L) at minute 60 in a pH 1.2 medium was 57.50% ± 1.33 and in a pH 4.5 medium was 86.24% ± 0.69. Statistical analysis of the total flavonoid content (mgQE/gram) in the extract, sprinkle formulation, and the amount of dissolved drug at minute 60 in pH 1.2 and pH 4.5 medium yielded a p-value < 0.05, indicating a significant difference in total flavonoid content among the samples. Conclusion: Sprinkle formulation of noni fruit extract provides significantly different dissolution profiles at pH 1.2 and pH 4.5.
References
Asare-Addo, K., Conway, B. R., Larhrib, H., Levina, M., Rajabi-Siahboomi, A. R., Tetteh, J., Boateng, J., & Nokhodchi, A. (2013). The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matrices. Colloids and Surfaces B: Biointerfaces, 111, 384–391. https://doi.org/10.1016/j.colsurfb.2013.06.034.
Ayuningtyas, N., Natalie, C., Monalisa, A., Pramitaningastuti, A. S., & Arianditha P, E. (2024). Optimization of Povidone and Sodium Starch Glycolate Formulas in the Formulation of Solid Sow of Noni Fruit Extract (Morindacitrifolia L.). International Journal of Pharmaceutical Research and Applications, 09(05), 1108–1116. https://doi.org/10.35629/4494-090511081116.
Chanthira Kumar, H., Lim, X. Y., Mohkiar, F. H., Suhaimi, S. N., Mohammad Shafie, N., & Chin Tan, T. Y. (2022). Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent. In Integrative Cancer Therapies (Vol. 21). SAGE Publications Inc. https://doi.org/10.1177/15347354221132848.
Jurasekova, Z., Domingo, C., Garcia-Ramos, J. V., & Sanchez-Cortes, S. (2014). Effect of pH on the chemical modification of quercetin and structurally related flavonoids characterized by optical (UV-visible and Raman) spectroscopy. Physical Chemistry Chemical Physics, 16(25), 12802–12811. https://doi.org/10.1039/c4cp00864b.
Kristiana, M., Fitriyana, F., & Kurnyawaty, N. (2023). Pengaruh Waktu Maserasi terhadap Senyawa Flavanoid dari Umbi Bawang Dayak. Jurnal Teknik Kimia Vokasional (JIMSI), 3(2), 66–71. https://doi.org/10.46964/jimsi.v3i2.547
Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: An overview. In The Scientific World Journal (Vol. 2013). ScientificWorld Ltd. https://doi.org/10.1155/2013/162750.
Mali, S. S., Hajare, A. A., Nitin, B. B., AdhikraoV, Y., SachinS, M., Rohan, K. A., Ashok, H. A., Sachin, S. S., & Sameer, N. J. (2014). A review on development of biorelevant dissolution medium. A REVIEW ON DEVELOPMENT OF BIORELEVANT DISSOLUTION MEDIUM. Journal of Drug Delivery & Therapeutics, 2014(2), 140. http://jddtonline.info.
Mufidah, Z., Rifa’i, M., Laboratorium, R., Hewan, F., Biologi, J., Matematika, F., Pengetahuan, I., Universitas Brawijaya, A., Malang, J. V., & Timur, J. (2013). Aktivitas Imunomodulator Ekstrak Buah Mengkudu pada Mencit yang Diinfeksi Staphylococcus aureus. Jurnal Veteriner Desember (Vol. 14, Issue 4).
Pasupuleti Sunitha, Shaik Muneer Pasha, Siliveru Anil kumar, Souvik Samanta, S. Soumya, & Shaistha Tarannum. (2024). A Review on Dissolution Method Development and Validation. IJPAR JOURNAL, 13(4), 709–715. https://doi.org/10.61096/ijpar.v13.iss4.2024.709-715.
Perez-Chauca, E., Alva-Plasencia, P. M., & Ferraz, H. G. (2022). Development and validation of ultraviolet spectrophotometric methods for lamivudine and zidovudine quantification in dissolution test. Journal of Pharmacy and Pharmacognosy Research, 10(5), 865–874. https://doi.org/10.56499/jppres22.1433_10.5.847
Sagala, R. J. (2019). Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 5(1), 84–92. https://doi.org/10.22487/j24428744.2019.v5.i1.12360.
Sharma, S., & Thakkar, M. (2019). Development and validation of UV-Visible Spectrophotometric method for the estimation of Qercetin in Herbal Dosage forms Development and Validation of UV-Visible Spectrophotometric Method for the Estimation of Quercetin in Herbal Dosage Forms. https://www.researchgate.net/publication/374264204.
Vyshnavi, K., Sinduja, Y., Adeyemi, P. G., Ebuka, A. D., Srija, M., & Sushma, G. (2022). A Review Article on Dissolution Studies in Novel Drug Delivery System. Journal of Drug Delivery and Therapeutics, 12(3), 220–225. https://doi.org/10.22270/jddt.v12i3.5337.
Weerapol, Y., Tubtimsri, S., Jansakul, C., & Sriamornsak, P. (2017). Improved dissolution of Kaempferia parviflora extract for oral administration by preparing solid dispersion via solvent evaporation. Asian Journal of Pharmaceutical Sciences, 12(2), 124–133. https://doi.org/10.1016/j.ajps.2016.09.005.
Zarekar Shivani Gulab, Raykar Sonali Dattu Zende Gauri Sampat, & Puranik Aboli K and Sanjay J. Ingle. (2024). A review on the wet granulation technique and its modules. World Journal of Biology Pharmacy and Health Sciences, 20(2), 113–124. https://doi.org/10.30574/wjbphs.2024.20.2.0836.
1.png){kind=small}
