Co-Processed Laktosa-Metilselulosa Sebagai Zat Tambahan Tablet Dengan Metode Kempa Langsung
Abstract
ABSTRAK
Co-processing is a technique to obtain a new excipient by combined two or more excipients with an appropriate process. Excipient by co-processing can improve the properties of excipient. The purpose of this research is to produce an excipient with good properties by co-processed Lactosa-Methylcellulosa, so that it is can be use as an excipient for direct compression tablet. This research was compared co-processed Lactosa-Methylcellulosa fabricated by wet milling technique. The co-processed material obtained were evaluated; particle size distribution, average diameter, density, porosity, carr’s index, flowability,compactibility and DSC. And they have been compared with their’s physical mixture. The flowability of co-processed Lactosa-Methylcellulosa was increasedbased on measurement by angles of reposewho did’nt passed 25o, in the range of 16.16 ± 0.63 to 18.59 ± 1.29 and the tensile strength of co-processed Lactosa-Methylcellulosa was increased until 1.79 MPa was higher than it’s physical mixturewere not can be measured tensile strength because the tablet not be able to be developed whole.DSC result of co-processed had similiar pattern with Lactosa. The co-processed Lactosa-Methylcellulosa is more promising to use as direct compression material.
References
Aulton, M. E., 1998, Tablets, In: M. H. Rubinstein, ed. Pharmaceutics the Science of Dossage From Design, London: Churchill Livingstone
Burcham, C.L., Collins, P.C., Jarmer, D.J., dan K.D. Seibert., 2009, Reduction of Particle Size of Drug Substance for Low-Dose Drug Products. In, J. Zheng (eds). Formulation and Analytical Development for Low-Dose Oral Drug Products. Hoboken: John Wiley & Sons, Inc, 207, 209-216
DFE pharma, 2012,Directly compressible lactose, hal 3.
Gohel, M.,C., 2005, A Review of Co-Processed Directly Compressible Excipients, J Pharm PahrmaceutSci, 8(1): 76-93.
Kaialya, H., Chikwanha, B., Shojaee, S., Nokhodchi, V., 2014, An approach to Engineer Paracetamol Crystals by Antisolvent Crystallization Technique in Presence of Various Additives for Direct Compression. International Journal of Pharmaceutics;464, p. 53-56.
Martinello, T., Kaneko, R., Velasco, S., Taqueda., 2006, Optimatization of Poorly Compactable Drug Tablets Manufactured by Direct Compressing Using The Mixture Experimental Design. Int. J.Pharm; 322 p. 87-95.
Mulye, P., Jamadar, A., Karekar, S., Pore, V., Dhawale, C., 2012,Improvement in Physicochemical Properties of Ezetimibe Using a Crystal Engineering Technique, Powder Technol;222, 131-138.
Qiu,Y., Chen, Y., Zhang, G., Liu, L., 2009, Developing Solid Oral, Pharmaceutical Theory and Practice, Charon Tec Ltd. USA : A Macmillan Company; 136.
Rowe, R. C., Sheskey, P. J., and Quinn, M. E, 2009, Handbook of Pharmaceutical Excipients (6th ed), Pharmaceutical Press, London.
Shangraw, R.,f., & Bandelin F.,J., 1989, Compressed tablet by Direct Compression, in Liebermen, H.A., Lachman L, Pharmaceutical dosage froms; Tablets, Vol. 1;197,198, Marcel Dekker Inc., New York : Basel.
Siregar, J.,P, 2010, Teknologi Farmasi Sediaan Tablet, Dasar-dasar Praktis,Jakarta, Hal: 1-2, 144-145, 159-160, 164, 178, 181-182, 193, 509-515.
Zhou D, & Qiu Y., 2010, Understanding Material Properties in Pharmaceutical Product Development and Manufacturing : Powde Flow and Mechanical Properties, Journal of Validation Technology.
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